Investigation and Validation of the Impact of Local Characteristics on Clinical Decision Support Systems for early Sepis Prediction
11 / 2020 – 05 / 2021
Sepsis is a common and deadly disorder leading to more deaths per year than breast cancer and
prostate cancer combined . While not receiving any antibiotic treatment, the mortality rate
drastically increases by 7.6% per hour . An early diagnosis therefore has a high impact on
patient outcome and is a key factor in sepsis treatment [1, 3].
A solution to help physicians with nding a diagnosis by using various parameters are clinical
decision support systems. Early sepsis prediction algorithms are an example for such systems.
However, they have not been used in clinical practice yet, due to the wide range of symptoms
sepsis can yield and no unique biomarker that can diagnose sepsis condently until now [3, 4].
This leads to algorithms that are not specic and sensitive enough for clinicians to be useful [4, 5].
The assumption though is, that sepsis diagnosis depends on local conditions like the denition
of sepsis, available biomarkers, or demographics . Therefore, an algorithm might be greatly
improved by incorporating local circumstances into the development process.
Thus, the aim of this research is to investigate how local circumstances dier in various countries
and settings and to validate two algorithms with both publicly available patient data merged from
several ICU departments and local patient data.
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